3. PCR Glabridin Mechanism for Skin Whitening
Normally,the cause of skin darkening is tyrosinase and reactive oxygen species.Tyrosinase can regularly produce melanin, making the skin black. And external stimuli (including common ultraviolet rays, inflammation, allergies, etc.) can cause excessive secretion of tyrosinase, which makes the skin black.Glabridin is an excellent melanin inhibitor. Firstly, with the participation of glabridin, the activity of tyrosinase is significantly inhibited, thus blocking the biosynthesis of melanin in the skin. Secondly, glabridin can inhibit two proteins required in the process of melanin formation, thus blocking the enzymatic reaction to reduce the effect of melanin synthesis. Thirdly, glabridin can act as an endothelin antagonist to reduce the regulation of endothelin on the proliferation of melanocytes, thus reducing melanin production and achieving skin whitening effect.
Glabridin is currently a whitening ingredient with good curative effects and comprehensive functions, with good safety. However, due to the poor water solubility and low transdermal absorption, it is not possible to add a large amount of glabridin into cosmetics, which affects its efficacy.